To satisfy the sustainable operation development, the establishment of newgeneration data centers has becoming a common sense. According to the definition of the Uptime Institute (UI), the availability and reliability of data centers will be improved obviously when they evolve from basic, component redundancy level to the concurrently maintainable and faulttolerant level. To meet the increasing demands on the time effectiveness for the large volume of remote sensing data transmission and processing and the fast growing requirements for system computing and storage capabilities, the six key technologies for the Newgeneration Data Center (NDC) are investigated. Based on these technologies, the application and practice put their emphases on the dynamic resource deployment automation, resource effective usage optimization, unified infrastructure and facilities management, solid resource and data protection mechanism, scalable information technical architecture, energy conservative or green computing technologies, product adoption, etc, which will facilitate the successful construction and operation of a newgeneration remote sensing data center. In combination with the implementation of the FY3A ground application system, the best practice is presented for the implementation of six key technologies to set up a newgeneration remote sensing data center.