Based on the regional high-temperature process’s classification standards and by using the daily maximum temperature data, the regional high-temperature events in Shandong Province are objectively identified. The spatio-temporal distribution and variation characteristics of regional high-temperature events and their response to climate warming are also analyzed. The results show that there are 154 regional high-temperature events in Shandong Province from 1961 to 2020, with an average of about 2.6 times per year. These events, in general, occur from June to July. Over the space, regional high-temperature events are mainly distributed in the western region of Shandong Province and less in the mountainous and coastal areas. There are obvious inter-annual and inter-decadal changes in the occurence frequence of regional high-temperature events, with a shift from a downtrend to an uptrend. The occurence frequence of regional high-temperature events decrease significantly from the 1960s to the 1980s and increase after the mid-1990s, with a significant increase in the 21st century. These events’ duration, region and intensity also increase and enhance significantly in the 21st century. Regional high-temperature events have a significant response to climate warming. With the intensification of warming, the annual latest occurrence time of regional high temperature is obviously delayed. Regional hightemperature events become more frequent, longer and stronger, with a larger influence range. And the longer and stronger regional high-temperature events are also more likely.