The route flight temperature data are the basis of researches on route adaptability analysis, sailing analysis, and aircraft selection. Based on the NOAA historical meteorological data, this paper establishes a function model with the highest fitting degree to the original temperature data through statistics, analysis and fitting of the original temperature data, and constructs a rapid temperature estimation method for the waypoint based on the characteristics of temperature and frequency density curves. The typical latitude and longitude grid points are taken as examples. The calculation results of the direct statistical calculation and rapid estimation methods are compared with the calculation results of the Boeing WINDTEMP.EXE software. It is shown that the method for calculating the temperature of the waypoints based on statistical calculation has the advantages of accurate and reliable calculation, but the speed is slow and it is difficult to meet the operational requirements of civil aviation, but the method for rapid temperature estimation of the waypoints based on the characteristics of temperature and frequency density curves studied in this paper has the advantages of high accuracy and fast operation speed, and can meet the real needs of civil aviation operations.