An analysis is made of the correlation between atmospheric instability parameters and lightning activities in the low latitude plateau region in this paper using the lightning information and radiosonde data in Yunnan Province from 2014 to 2017 Five parameters selected from 9 are strongly correlated. The threshold of lightning occurrence for each parameter is determined by means of the mathematical method. The complex correlation coefficient method is used to calculate the weight of each parameter and set up the prediction equation for lightning potential. Finally, the equation is verified by means of forecasting and case analysis. The results show that the atmospheric instability parameters over the low latitude plateau are sensitive to lightning activities. The response threshold is generally lower than that of the plain area. The prediction effectiveness of the prediction equation is significant for the occurrence of lightning activity in the next 12 hours. The equation has good promotion and application value.