Based on the data of environmental monitoring and meteorological elements in Hubei Province in 2015 and 2016, this paper analyzes the characteristics of air quality and its relationship with meteorological factors in three kinds of terrains. The results show that the temporal and spatial distribution of air quality in Hubei Province was low in mountain and high in plain areas, and the high value of AQI in winter and low value of that in summer. It is shown that the daily maximum AQI of Xiangyang appeared at noon, and the highest value of Wuhan and Yichang appeared from 23:00 to 24:00 Meteorological factors that have obvious relationship with air quality include relative humidity, variable temperature and pressure, wind, precipitation, of which precipitation effect on pollutant sedimentation is related to the air quality grade. The heavier the pollution, the greater the amount of rain needed to clean the air. For mild and above pollution, moderate and above precipitation will be effective for clean air. When precipitation is in trace level (below 1 mm), there will be a growing trend in AQI. Under different terrain influences, there blew mainly north winds in Xiangyang, northwest winds in Wuhan and the weak easterly wind disturbance in Yichang in case of heavy pollution. The occurence frequency of large wind speed in Xiangyang was obviously higher than the others, and Yichang was dominated by breeze.