In accordance with the monthly global solar radiation and percentage of sunshine at 10 solar radiation observation stations in Guizhou Province during 2011-2015, the experiential coefficients in the formula are fitted in terms of the least square method. The monthly model of the parameters with the change of geographic location is established by combining with the geographic information (latitude and altitude) of the corresponding stations. Then, based on radiation data at Weining Station from 1962 to 1990, independent sample tests are carried out. At the same time, the data of Guiyang Station from 2001 to 2010 are compared with the results from the altitude partition method. The monthly total solar radiation for 85 weather stations in Guizhou Province is calculated on the basis of the determined climatic equation by the sunshine duration data and the geographic information during the period of 1981 to 2010, and the temporal and spatial distributions of total solar radiation are analyzed in detail. The results show that the calculation of solar radiation in Guizhou Province by using the monthly model of parameters had less error and higher precision, which can improve the accuracy of solar radiation calculation; the simulated solar radiations was significantly related to the observation values; the annual variation of global solar radiation took onepeak form with maximum in July and minimum in January. The annual global solar radiation in the province ranged from 341576 MJ〖DK〗·m-2 to 473704 MJ〖DK〗·m-2 from southwest to north. The minimum annual solar radiation was at Wuchuan and Maximum at Weining.