Human comfort has a significant impact on people’s work and life, and studies of human comfort under different weather conditions are important in public meteorological service. Using the atmospheric detection technology and means, the temperature and humidity were obtained at three times (07:00,13:30,19:00) a day in four typical observation sites in the Chengdu University of Information Technology from June 2013 to March 2014. The difference of indoor and outdoor human comfort is analyzed under typical cloudy and clear days, and the correlation of indoor and outdoor human comfort is studied by using the temperature and humidity index (THI). The results show: (1) On sunny days, the number of comfortable days is the greatest in the crowded indoor environment, accounting for 61% of the total number of days; on cloudy days, the number of comfortable days is the least in the outdoor environment, constituting 40% of the total number of days. (2) The biggest difference in human comfort under different weather conditions is in summer. On sunny days, the human comfort in small rooms with less people is the best, while outdoor comfort is the worst. However, on cloudy days, outdoor comfort is the best, while the human comfort in big crowded rooms is the worst. (3) On cloudy days, a significant correlation is found in temperature and humidity indexes between less crowded small indoor and outdoor environment, the correlation being the best (〖WTBX〗R2 〖WTBZ〗=0.97), while the correlation is the worst (〖WTBX〗R〖WTBZ〗2=0.92) between large crowded indoor and outdoor temperature and the humidity indexes.