In order to provide a basis for the deployment and countermeasures of disaster prevention and mitigation work in Qinghai Province, through analyzing the variation regularity and spatial distribution patterns of frost disasters from 1961 to 2010, based on the historical data of daily minimum temperature, total crop planting area, the yield of crops, etc., in Qinghai Province, the risk regionalization of frost disasters is carried out and the variation characteristics of frost disasters are analyzed by means of the graphics, exponential product method. The statistic method is used to build the hazard, exposure and sensitivity indexes of disasterinducing factors. The results show that all the crop planting areas in Qinghai Province are attacked by frost disasters, which are concentrated in Delingha, Dulan and Wulan counties in the eastern Qaidam basin, Menyuan, Datong, Huzhu and Huangzhong counties in the eastern agricultural area, and Guinan and Gonghe. Frost disasters happen mainly from April to September, and the frequency of occurrence reaches the highest in May. The interannual variation of frost disasters exhibits an increasing trend, but not significant, while the interdecadal variation of frost disasters shows a significantly increasing trend. The high risk areas of frost disasters include Menyuan, Huzhu, Datong, the eastern Qilian in the northeast of Qinghai.