The multi year spatial distribution and variations of liquid water content and particle effective radiuses in Southwest China are analyzed by using MODIS data from NASA Goddard Earth Science DAAC from 2000 to 2010 The results show that annual and seasonal liquid water content at high latitudes is greater than that at low latitudes; the annual and seasonal particle effective radiuses have the opposite distributions. Liquid water content has seasonal difference, higher in autumn and summer, and lower in spring and winter; particle effective radiuses have smaller seasonal difference. There is a decreasing trend in annual liquid water content from 2000 to 2010, as well as in spring and winter, and there is no obvious trend in particle effective radius.