Natural clouds and fogs in the atmospheric environment are important factors which affect the precision of optically guided weapons. However, because of the nonreproducibility of natural clouds, it is hard to study the impact of clouds on the optically guided weapons. In order to assess the impact of natural clouds on the operation of optically guided weapons preferably, it is necessary to carry out the simulation of natural clouds in cloud chambers. Based on the brief introduction of artificial fog researches and the main features of a fog laboratory, the control of spray, catalyst release, temperature, humidity, airflow, and illumination in the process of artificial fog making is described in detail. The development trends of artificial fog researches in the future are also discussed.