By means of the recent 9year lightning disaster and 45year thunderstorm day and 4year cloudtoground lightning flash data in Jiangsu Province, an analysis is made of the distributions of lightning disasters in 13 cities based on the background of natural and human culture environment in Jiangsu Province. It is point out that lightning disasters mainly occur from June to August, and damages are mainly found in physical devices and electricity and electronic systems, with Wuxi and Suzhou being most typical. Vulnerability indexes are extracted and calculated, and the comprehensive assessments are made on these indexes using the method of the principal component analysis with SAS software. The results indicate that the regional thunder disaster vulnerability is depended on not only the sensitivity of the regional natural condition to the environmental variation of the lightning magnetic field and but also the bearing capacity of the social system in the region to lightning disasters. The vulnerability regionalization chart of lightning disasters in Jiangsu Province, based on cluster analysis, is given, which can provide a scientific basis for regional lightning protection and disaster reduction.