Analyses is made of the atmospheric environment variation during the flu rages in 1998 and 2000. The results indicate that such atmospheric environment variation as higher winter air temperature, fewer cold air activities, larger argument of temperature variation, fewer precipitation than previous year along with greater inter annual variation and uneven temporal distribution, and higher atmospheric soot content are related closely to flu occurrence. At the same time, using the 11 year diseases case history information and the multiple regression method, selecting three factors with distinct physical meaning, a prediction equation of flu is established.